Clinical Studies

Clinically proven

Two clinical studies confirm that Sweet Defeat reduces desire for sugar and sugar consumption.

Journal of Psychopharmacology

Gymnemic acids (GA) suppress sweet taste and reduce consumption of high-sugar foods (HSF) which has been attributed to the reduction in pleasure. Herein we tested whether GA reduces the desire to eat HSF, before any HSF is tasted post GA dosing, which would implicate another mechanism of action not previously examined. In this double-blind experiment, 67 adults selected a favourite candy, consumed one standardized serving, rated candy pleasantness along with desire for more candy, and were randomly assigned to consume a GA or placebo lozenge. They subsequently completed candy desire ratings and were offered additional candy servings, one at a time. If an offering was accepted, it was consumed, pleasantness and desire ratings were reported, and another serving was offered. The GA lozenge versus the placebo produced a 31% reduction in participants who chose to eat the first candy offering after GA dosing and produced a 44% reduction in total candy intake. GA versus placebo participants who ate at least one optional serving reported reduced candy pleasantness, though reductions in reported desire did not reach significance. The GA lozenge reduced candy consumption and desire for candy, providing novel evidence that blockade of sweet taste receptors reduces desire for sweet food, even before the food is tasted after GA dosing.

Journal of Advancement in Medicinal Plant Research

Reduction in sugar intake can have a positive effect on body weight and increased intake a negative impact. Gymnemic acids (GA) are antagonists at tongue glucose receptors thus blunting sweet taste. In a previous study GA were formulated in a lozenge, and administered to healthy subjects. Results showed that the lozenge, containing GA, significantly reduced endpoints of intake and pleasantness for high sugar foods (HSF), but desire for HSF was not significantly reduced. The present trial re-examined the lack of significance in desire in the previous study, with greater number of subjects, additional inclusion criteria and used a cross over design to assess carryover effects. Percent of subjects who choose to eat the first candy offering subsequent to the GA lozenge dosing, total candy consumption, pleasantness and desire ratings were assessed. Desire rating for a second candy offering immediately after the GA lozenge, but before tasting a second candy, was significantly reduced by comparison to placebo. Additionally, study design improvements broaden the demographic applicability of this lozenge GA approach. No order effects were observed during the crossover. Subjects given the GA lozenges also ate less candy, less often and their perceived pleasantness for their preferred candy was reduced. The GA lozenges significantly reduced desire for and consumption of HSF relative to a placebo. This study provides further support regarding the role of GA in carbohydrate intake reduction, and broadens their potential applications as aids in supporting a healthy weight.
* Sweet Defeat was formerly marketed as Crave Crush.